Symbol
Name
ID

Apc
APC, WNT signaling pathway regulator
MGI:88039

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Lymphadenopathy	Hepatosplenomegaly	Peritoneal abscess	Subacute progressive viral hepatitis
Disease(s) Associated with APC	Lymphadenopathy	Hepatosplenomegaly	Peritoneal abscess	Subacute progressive viral hepatitis
hepatocellular carcinoma
pancreatic cancer

Mouse Phenotypes

abnormal thymus morphology

abnormal Hassall's corpuscle morphology

small thymus

thymus hypoplasia

decreased thymocyte number

abnormal T cell differentiation

increased double-negative T cell number

arrested T cell differentiation

increased mast cell number

decreased NK cell number

decreased NK T cell number

decreased T cell number

decreased macrophage cell number

abnormal effector T cell morphology

decreased splenocyte number

abnormal NK T cell physiology

increased circulating tumor necrosis factor level

enlarged mesenteric lymph nodes

lymph node hyperplasia

increased interferon-gamma secretion

abnormal interleukin secretion

increased interleukin-4 secretion

liver inflammation

Availability

Mouse Genotype

Apc^Min/Apc⁺

Apc^Min/Apc⁺
Tg(Rorc-EGFP)1Ebe/?

Apc^tm1Kk/Apc^tm1Kk
Tg(Lck-cre)1Cwi/? (conditional)

Apc^tm2.1Cip/Apc^tm2.1Cip
Tg(Ttr-cre/Esr1*)1Vco/0 (conditional)

Apc^tm2Rak/Apc^tm2Rak
Tg(KRT14-cre)8Brn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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